Mass accuracy in HRMS refers to the precision and correctness with which the mass spectrometer measures the m/z of ions. It quantifies the degree to which the measured m/z values of ions correspond to their true or expected values.

While a triple quadrupole mass spectrometer offers excellent selectivity, there remains a possibility of a compound other than the target analyte to produce a signal with a similar m/z value to the qualifying or quantifying ion at the same retention time.

The monoisotopic mass, also known as the exact mass of a molecule, is determined by adding the exact masses of the most abundant isotopes of its component elements.

Analysis of chemical compounds by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in complex samples presents unique challenges that should be considered.